In this stop-motion-animated film from writer/director Wes Anderson, an outbreak of canine flu in Japan leads all dogs to be quarantined on an island. A boy (voice of Koyu Rankin) journeys there to rescue his dog Spots (Liev Schreiber), and gets help from a pack of misfit canines who have also been exiled. His quest inspires a group of dog lovers to expose a government conspiracy. The voice cast also includes Bryan Cranston, Edward Norton, Bill Murray, Scarlett Johansson, Tilda Swinton, Bob Balaban, Greta Gerwig, and Yoko Ono.